Appointment Boosts Neuro Research in Plymouth

Plymouth University Peninsula Schools of Medicine and Dentistry has appointed Dr. Claudia Barros to the post of lecturer in neuroscience.

Dr. Barros obtained her five-year Diploma in Biology from the Lisbon Sciences University, Portugal, followed in 2003 by her PhD from the University of Cambridge.

In late 2003, she became a postdoctoral associate fellow in the laboratory of Professor Ulrich Müller at the Dorris Neuroscience Center of The Scripps Research Institute, San Diego, USA. Her studies focused on cellular and molecular mechanisms which influence neural development and function.

Dr. Barros returned to the UK in Autumn 2009 and after a brief stay at the Wellcome Trust Center for Human Genetics, Oxford University, she was awarded an Early Career Fellowship from the Leverhulme Trust, UK to start in late 2010 as a Research Fellow at Bangor University, Wales.

In her new post at Plymouth University Peninsula Schools of Medicine and Dentistry, her research team investigates regulatory mechanisms responsible for the development and maintenance of postembryonic neural stem cells in the brain in normal and disease conditions, such as during brain tumour formation.

Current research primarily makes use of the central nervous system of the fruit fly (Drosophila melanogaster) as a model, and involves functional genetics, gene expression and imaging studies to identify the underlying signals that control postembryonic neural stem cell activation, cell fate and cell differentiation.

Research has been published in a number of respected journals, including Developmental Cell, Molecular Psychiatry, Journal of Neuroscience, Development and Proceedings of the National Academy of Sciences of the United States of America (PNAS).

Dr. Barros joins a growing and leading research team in Plymouth investigating neurodegenerative disorders, ischemia and brain tumours.

Ends

Note to Editors

Dr. Claudia S. Barros – Publications

Bossing, T., Barros, C.S., Fisher, B., Russell S. and Shepherd, D. (2012) Disruption of microtubule integrity triggers mitosis during CNS repair. Dev. Cell, Aug; 23(2):443-440.

Cahill, M.E., Jones, K.A., Rafalovich, I., Xie, Z., Barros C.S., Müller, U., Penzes, P.. (2012) NRG1/erbB4 control interneuron dendritic growth through kalirin-7 dysinhibition, Mol. Psychiatry, 17(1)1-107.

Barros, C.S. Franco, S.J. and Müller, U. (2011) Extracellular matrix: functions in the Nervous System. Cold Spring Harb Perspect Bio., Jan 1;3(1) pii:a005108.

Barros, C.S., Nguyen, T., Kathryn S. R. Spencer, Colognato, H and Müller, U. (2009)  integrins are essential for CNS myelination and promote Akt-dependent myelin outgrowth Development, Aug; 136(16): 2717-24.

Radakovits, R., Barros, C.S., Belvindrah, R., Patton, B. and and Müller, U. (2009) Survival of radial glia is controlled by interactions with the meninges. J. Neuroscience, Jun; 17;29(24): 7694-705.

Barros, C.S., Calabrese, B., Chamero, P., Roberts, A., Korzuz, E., Lloyd, K., Stowers, L., Mayford, M., Halpain, S., and Müller, U. (2009) Impaired maturation of dendritic spines without disorganization of cortical cell layers in mice lacking NRG1/ ErbB signalling in the central nervous system. PNAS Mar; 46(2): 251-258.

Barros, C.S. and Müller, U. (2006) Integrin Functions in Nervous System Development. In: Integrins in Development. E. Danen (Ed). Landes Bioscience, Georgetown, TX.

Barros C.S., Phelps C.B., Brand A.H. (2003) Drosophila nonmuscle myosin II promotes segregation of cell fate determinants by cortical exclusion rather than active transport. Dev. Cell. Dec.; 5: 829-40.

Bossing T., Barros C.S., Brand A.H. (2002) Rapid tissue-specific expression assay in living embryos. Genesis. Sep.-Oct.; 34(1-2): 123-6.

van Roessel P., Hayward N.M., Barros C.S., Brand A.H. (2002) Two-color GFP imaging demonstrates cell-autonomy of GAL4-driven RNA interference in Drosophila. Genesis. Sep-Oct; 34(1-2): 170-3.

Picture captions: Dr. Claudia Barros; Inside the fruit fly larval brain, a model to study how neural stem cells develop and function. Confocal microscope image showing in green postembryonic neural stem cells and their smaller daughter cells. Cells in division and further committed neural cells are labeled in blue and red, respectively.

(C. Barros image)

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